A magnetic resonance imaging study of hippocampal, amygdala and subgenual prefrontal cortex volumes in major depression subtypes: Melancholic versus psychotic depression

K Vassilopoulou; M Papathanasiou; I Michopoulos; F Boufidou; P Oulis; N Kelekis; E Rizos; C Nikolaou; C Pantelis; D Velakoulis; L Lykouras

Journal article

A magnetic resonance imaging study of hippocampal, amygdala and subgenual prefrontal cortex volumes in major depression subtypes: Melancholic versus psychotic depression

K Vassilopoulou, M Papathanasiou, I Michopoulos, F Boufidou, P Oulis, N Kelekis, E Rizos, C Nikolaou, C Pantelis, D Velakoulis, L Lykouras

Journal of Affective Disorders | ELSEVIER | Published : 2013

DOI: 10.1016/j.jad.2012.09.003

Abstract

Background: Volumetric studies examining brain structure in depression subtypes are limited and inconclusive. The aim of the current study was to compare the volumes of brain regions previously implicated in depression among patients with melancholic major depressive disorder (MDD), patients with psychotic MDD and normal controls. Methods: Twenty two patients with melancholic MDD, 17 with psychotic MDD and 18 normal controls were included in the study. Hippocampal (HV), amygdala (AV), anterior (ASCV) and posterior (PSCV) subgenual cortex volumes were measured on magnetic resonance volumetric images. Results: There were no volumetric differences between patients with melancholic and psychotic..

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University of Melbourne Researchers

Christos Pantelis Author

Dennis Velakoulis Author

Related Projects (3)

EMERGING MENTAL DISORDERS IN YOUNG PEOPLE: USING CLINICAL STAGING FOR PREDICTION, PREVENTION AND EARLY INTERVENTION

Mental disorders are a major cause of disability in Australia, especially for young people. We have developed a clinical staging model cover..

EMERGING MENTAL DISORDERS IN YOUNG PEOPLE: USING CLINICAL STAGING FOR PREDICTION, PREVENTION AND EARLY INTERVENTION

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RESEARCH FELLOWSHIP - PROF CHRISTOS PANTELIS

I have established and head the Melbourne Neuropsychiatry Centre within the University of Melbourne. My university position is a research ch..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

We wish to thank the Theodorou-Theohari Kotsika Foundation for its financial contribution to the study. Prof Christos Pantelis was supported by a NHMRC Senior Principal Research Fellowship (ID: 628386) and NHMRC Program Grant (ID: 566529).